Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking

Recruitment of multiple pathways to ventral tegmental area during cocaine-seeking behavior.

Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see The mesocorticolimbic dopamine system is a major neural substrate...

Opioid Agonists Inhibit Glutamatergic Input to Ventral Tegmental Area Neurons”

Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area

Cocaine is a highly addictive drug that acts upon the brain's reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine's effects through poorly understood mechanisms. We find that cocaine stimulates release of the eCB, 2-arachidonoylglycerol (2-AG), in the rat ventral midbrain to...

A role for conditioned ventral tegmental glutamate release in cocaine seeking.

Initiation of cocaine self-administration in rats was associated with release of glutamate in the ventral tegmental area (VTA). The glutamate release was transient, despite continued cocaine intake. Similar glutamate release was seen in rats earning, for the first time, unexpected saline rather than expected cocaine. VTA glutamate release was not seen in similarly trained rats earning saline in...

Evaluation of GABA Receptors of Ventral Tegmental Area in Cardiovascular Responses in Rat

Background: The ventral tegmental area (VTA) is well known for its role in cardiovascular control. It is demonstrated that about 20-30% of the VTA neurons are GABAergic though their role in cardiovascular control is not yet understood. This study is carried out to find the effects of GABA A and GABA B receptors on cardiovascular response of the VTA. Methods: Experiments were performed on uretha...